Coalition for African Research and Innovation (CARI)

The Need for Robust African Research & Development

The 17 Sustainable Development Goals paint an optimistic picture of what the world can look like in2030. On most targets, especially those related to poverty and disease, the countries of Africa have the furthest to go. In human terms, this means that the quality of life for more than a billion people onthe fastest-growing continent on earth hangs in the balance.

Our future depends on the rate at whichwe are able to solve some of the hardest health and development problems anyone has ever faced.To succeed, we need to create conditions that are conducive to scientific and technological innovation: more R&D partners with more skills, more funds, more support, and more ambition. That is what the Coalition for African Research and Innovation (CARI) exists to do: to accelerate scientific breakthroughsin Africa so that we can help more Africans lead better lives sooner.

The current landscape

Currently, to be blunt, there are not enough resources available for innovation in Africa, and we don’t get the most out of the resources that are available because they are so fragmented.

First, the lack of resources: Most obviously, funding for R&D in Africa is shockingly low: only 1.3 percent of the money spent globally on R&D is spent in Africa. This shortage of investment is both a cause and an effect of other resource constraints. For example, the proportion of researchers in the African population is 25 and 28 times lower than the proportion in the United Kingdom and the United States, respectively. The percentage of Africans pursuing graduate study is three times lower than the global average. There are similar gaps related to the facilities and equipment needed to conduct cutting-edge R&D. It’s a classic chicken and egg problem. African countries lack the infrastructure to support investment in R&D, and they lack the investment in R&D to build up the infrastructure.

Second, the fragmentation of resources: The individuals, organizations, and governments that fund and conduct R&D on the continent do not have any mechanism for systematic collaboration. As a result, they forego the efficiencies and network effects you’d expect from an innovation collaboration and leave no permanent capacity in place at the end.

Without a doubt, many individual projects have been impressive successes, but even the most successful aren’t always connected to the full range of expertise needed to get to the point of impact. This is especially true when it comes to translational expertise, with many great discoveries never crossing over the so-called valley of death between discovery and the introduction of a new product or service that changes lives. Perhaps most damaging, the fragmentation results in a lack of coordinated strategic planning for African R&D.

Few stakeholders have the remit to think about the long-term investments and policies needed to build a thriving African science and technology sector that responds to the needs of the African people.


Building a highly coordinated, well-funded,  and African-led African innovation enterprise.

CARI’S Approach

CARI, an initiative under the auspices of the Alliance for Accelerating Excellence in Science in Africa (AESA), aims to create a platform within Africa from which stakeholders can catalyze a highly coordinated, well-funded, innovative African R&D community together. It starts by bringing them together to engage in an ongoing, coordinated conversation— and we expect that this conversation will yield commitments to work together in new ways to meet short-term health and development objectives while building long-term capacity in the field. This conversation will be led by Africans and guided by African concerns, and it will include African governments, African development organizations,the African private sector, African and global philanthropists, global funders, and industry.

Through its broad network of relationships, CARI seeks to “Connect The Dots”: to support African innovation by linking people to one another, to ideas, and to resources, including funds and everything else that makes up a robust science and technology ecosystem, from mentorship to policy advice.

Ultimately, CARI hopes to trigger a Movement that makes science and innovation part of the public discourse in Africa. One of CARI’sfirst undertakings will be a rigorous study of the long-term benefits of investments in R&D to African economies, to underscore the fact that science and technology is a growth strategy— not an expense but an investment in the future.

We expect CARI will align stakeholders to issue calls for collaborative investment across sectors in specific R&D challenges for Africa, which would serve the purpose of de-risking investment by any individual stakeholder or sector. An African government is more likely to reach its stated target for R&D investment (1 percent of GDP) if it knows that private sector partners are on board to help usher discoveries through the development and delivery stages.

Likewise, private sector companies are more likely to invest resources in Africa if they know governments and other funders are committed to building a sturdy R&D infrastructure on the continent.


CARI is accountable to the CARI Leadership Group, representing African scientific thought leaders, international funders, and global industry leaders. CARI will be incubated, for up to five years, within the African Academy of Science (AAS), a pan-African academy of all sciences. As such, CARI will benefit from the investment of resources already directed at building the Alliance for Accelerating Excellence in Science in Africa (AESA) under AAS as a platform for setting the scientific agenda and implementing scientific programs.

CARI will be managed by a small team at AESA that will initially coordinate three task groups:

  • Partnerships, Advocacy & Engagement Working Group: Led by Nelson Torto, Executive Director of the African Academy of Sciences, the group will determine how CARI will fuel “African-Led Science for Sustainable Development” by aligning political and scientific leadership on the continent and directing money, focus, and mindshare to R&D.
  • Pharma Working Group: Led by Paul Stoffels, Chairman of Janssen Pharmaceuticals, the group will create health solutions for Africa by facilitating stronger collaborations between African scientific institutions and the global pharmaceutical industry.
  • Investment Working Group: (Lead TBD). The group will identify and implement creative financing mechanisms to catalyze R&D investments by African and global governments and institutions. CARI will build on African governments’ commitments through the Science, Technology and Innovation Strategy (STISA) 2024.

CARI envisions more working groups over time. After the incubation period, the leadership group will review CARI’s status and governance.

CARI Leadership Group

  • Ibrahim Mayaki, PhD / CEO, NEPAD Agency
  • Francis Collins, MD, PhD / Director, National Institutes of Health, USA
  • Jeremy Farrar, OBE, FRCP, FRS, FMedSc / Director, Wellcome Trust
  • Georg Schütte, PhD /State Secretary, Federal Ministry of Education and Research, Federal Republic of Germany
  • Chris Karp, MD / Director of Discovery & Translational Sciences, Bill & Melinda Gates Foundation
  • Paul Stoffels, MD / Executive Vice President, Chief Scientific Officer, Johnson & Johnson
  • Sir Andrew Witty / Former CEO, GlaxoSmithKline
  • Arnaud Bernaert, MBA / Head of Global Health and Healthcare Industries and System Initiative, World Economic Forum
  • Phil Thomson / President, Global Affairs, GlaxoSmithKline
  • Nelson Torto, PhD / Executive Director, African Academy of Sciences

CARI Steering Group

  • Aggrey Ambali, PhD /Head of Industrialization, Science, Technology and Innovation, NEPAD Agency
  • Robert Eiss / Senior Global Health Adviser to the National Health Institutes Director, USA
  • Tom Kariuki, PhD / Director, Alliance for Accelerating Excellence in Science in Africa
  • Simon Kay / Head, International Operations and Partnerships, Wellcome Trust
  • Kedest Tesfagiorgis / Program Officer, Grand Challenges Partnerships and Advocacy, Bill & Melinda Gates Foundation